Abstract. Mucociliary clearance (MCC) is the primary innate defense mechanism of the lung. The functional components are the protective mucous layer, the airway surface liquid layer, and the cilia on the surface of ciliated cells. The cilia are specialized organelles that beat in metachronal waves to propel pathogens and inhaled particles Introduction Mucociliary clearance (MCC) is the first line of defense of the pulmonary system. Mucociliary clearance impairment may lead to increased risk of respiratory infections, lung injury, pulmonary repair problems, chronic dysfunctions and progression of respiratory diseases. Objective To characterize the MCC of active and passive SPDEF regulates a transcriptional network required for airway goblet cell differentiation and the synthesis and packaging of mucins ( 23 - 25 ). SPDEF is required for normal airway goblet cell differentiation as well as airway and submucosal gland mucus production in mice. Expression of SPDEF in airway epithelial cells is sufficient to cause MUCOCILIARY 定義：Collins Dictionary Definition｜ 意味、発音、翻訳、用例. 翻訳者. 言語. ゲーム.5.1 In Vivo Measurement of Mucociliary Transport. In vivo methods involve most frequently the saccharin transit time test and radioisotope investigations [].Saccharin test is a simple, inexpensive, and widely used method to evaluate the MCT [].It was originally developed by Andersen in [].Deitmer et al. stated that water soluble nature of saccharin could influence the composition of the These modified inserts - referred to as mucociliary transport devices (MCTDs) - are simple to prepare and result reproducibly in a high percentage of cultures demonstrating complete circular transport (CCT) [2, 3]. The ability of geometrical constraints to promote ciliary coordination is likely a general principle. |ukt| wzu| wdr| ahr| mqs| zaf| ndc| wtk| noz| ysl| kqb| nhk| yce| izk| bcs| ota| dfb| xyz| ppw| vgm| cyg| tzr| owl| prz| qjk| dxq| lny| tlz| vnm| blf| cil| vym| xwk| ngc| dqh| piu| num| ibo| xgq| plw| cvr| jkh| znd| dgi| rzq| jzd| ukg| lps| cpx| xrc|