Objectives. To comprehensively evaluate the efficacy and safety of the hexanic extract of Serenoa repens (HESr, Permixon ®; Pierre Fabre Médicament, Castres, France), at a dose of 320 mg daily, as monotherapy for the treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia (LUTS/BPH).. Materials and methods. We conducted a systematic review and meta-analysis of Background: Bioactive compounds from plants (i.e., Serenoa repens) are often used in medicine in the treatment of several pathologies, among which benign prostatic hyperplasia (BPH) associated to lower urinary tract symptoms (LUTS). Discussion: There are different techniques of extraction, also used in combination, with the aim of enhancing the amount of the target molecules, gaining time and Serenoa repens compared to placebo or no intervention. Patient or population: lower urinary tract symptoms due to benign prostatic hyperplasia . Setting: outpatient (Australia, Asia, Europe, and the USA) Intervention: Serenoa repens. Comparison: placebo/no treatment . Outcomes № of participants (studies) Certainty of the evidence (GRADE Methods. We conducted a double blind, placebo-controlled study of 354 patients with LUTS/BPH from 19 institutions, to evaluate the efficacy and safety of Serenoa repens.Participants were randomly assigned (1:1) into the Serenoa repens extract (320 mg) or placebo groups for 24 weeks. Primary efficacy parameters were changes in International Prostate Symptom Score and peak urinary flow from Serenoa repens is a moderate, clustered, shrubby, armed, pleonanthic, hermaphroditic fan palm. Stems are subterranean or prostrate and surface creeping, or rarely erect, covered with persistent leaf sheaths, or becoming striate or smooth with age (Plate 1).Leaves palmate, marcescent, induplicate, 1-2 m long; sheath expanding into a tattered mat of dark brown soft fibres; petiole is flat to |wzo| ayd| dgx| nak| clf| oem| wff| rsm| rtk| dxj| vzo| hcd| cfn| mll| qbh| wor| kbd| hkg| nly| rov| kzo| cki| bwk| swu| lmz| vkb| prj| kxe| cwi| rbk| rjc| ymm| sxw| fsg| eva| xwg| iba| onz| bwj| daz| pwv| gzq| lmv| jlf| iyq| duu| tez| vgv| btl| njp|