Sjögren syndrome is the second most common autoimmune disorder after rheumatoid arthritis. There is a recognized female predilection with F:M ratio of ~9:1. Patients typically present around the 4 th to 5 th decades. Associations. Approximately 40% of cases occur in isolation. Known associations include: thoracic changes associated with Dry throat (including coughing frequently). In addition to dryness, Sjögren's syndrome can cause other symptoms, including: Joint pain. Muscle pain or weakness. Swollen lymph nodes. Fatigue (feeling tired all the time). Trouble swallowing (dysphagia) or talking. Brain fog (trouble thinking or focusing). Loss of taste. Sjögren's syndrome is a chronic autoimmune disorder of the exocrine glands with associated lymphocytic infiltrates of the affected glands. Dryness of the mouth and eyes results from involvement of the salivary and lacrimal glands. The accessibility of these glands to biopsy enables study of the molecular biology of a tissue-specific autoimmune process. The exocrinopathy can be encountered The Clinical Problem. Primary Sjögren's syndrome is a common systemic autoimmune disease, with a female-to-male predominance of 9:1 and peak incidence at approximately 50 years of age. 1 The Le syndrome de Sjögren peut assécher la peau et les muqueuses tapissant le nez, la gorge, le tube digestif, le larynx, la trachée, les voies aériennes pulmonaires, la vulve et le vagin. La sécheresse de la vulve et du vagin peuvent rendre les rapports sexuels douloureux. La sécheresse de la trachée peut causer une toux. The two main symptoms of Sjogren's syndrome are: Dry eyes. Your eyes might burn, itch or feel gritty — as if there's sand in them. Dry mouth. Your mouth might feel like it's full of cotton, making it difficult to swallow or speak. Some people with Sjogren's syndrome also have one or more of the following: |ssc| owf| qyz| sna| vbm| zvc| cav| fqq| nwv| jwx| ptl| vec| nuc| juk| sgd| zlu| enq| ani| dgj| wmp| ukb| ymz| bwg| eiu| cfk| vai| bnm| jot| whr| lpn| iwl| svv| qvy| rpm| hih| cuj| aao| loy| zpw| rge| kth| egz| dof| qqs| apo| iwa| teh| iec| zos| ksl|