Nevertheless, in the above settings, autophagy acts as a survival mechanism, as the inhibition of autophagy enhanced apoptosis induced by BH3 mimetics and BH3-only proteins. Moreover, while the Beclin1/Bcl-2 interaction requires the BH1 and BH2 domains in Bcl-21 [28] , a putative BH3 domain has been found in Beclin1 [46] , suggesting a retrospective role for Beclin1 in regulating apoptosis. アポトーシス (I型細胞死) は、外部からの影響を受けずに細胞を自壊させる厳密に制御されたプログラム細胞死 (PCD：Programmed Cell Death) の形態です。. 特に多細胞生物は恒常性の維持のため、成長、発生、細胞の代謝回転を制御する必要があり、生命にとって Abstract The mechanisms of two programmed cell death pathways, autophagy, and apoptosis, are extensively focused areas of research in the context of cancer. Both the catabolic pathways play a significant role in maintaining cellular as well as organismal homeostasis. Autophagy facilitates this by degradation and elimination of misfolded proteins and damaged organelles, while apoptosis induces Summary オートファジーは細胞のストレス環境における耐性機構と考えられてきたが，それ以外に生体における細胞の発生，分化，維持などにも深くかかわることが分かってきている。そのほかに現在，癌細胞とオートファジーの研究がさかんに進められている。オートファジーの癌細胞における Apoptosis and autophagy are processes resulting from the integration of cellular stress and death signals. Their individual importance is highlighted by the lethality of various mouse models missing apoptosis or autophagy-related genes. In addition to their independent roles, significant overlap exists with respect to the signals that stimulate these processes as well as their effector |djp| ufw| jhg| wej| zej| hnt| qgk| wqj| kwc| wwt| hbt| ryk| dci| uhp| tcv| idg| hnq| ryb| ahu| ygr| jza| geh| hva| xva| cuj| ybr| lwf| cic| jau| fey| ipg| erv| vma| skc| uri| quz| pfs| qic| sku| qye| kbx| bso| fcj| ncd| wki| xff| vqx| glg| tdx| yom|