4038 Background: The most commonly used treatment methods for metastatic colorectal cancer (mCRC)are systemic chemotherapy, molecular targeted therapy and local treatment. The main chemotherapy drugs for mCRC include Irinotecan, Oxaliplatin and 5-Fu. V308 Research shows that FOLFOX and FOLFIRI can be standard first or second-line of each other in the treatment of metastatic colorectal cancer The recently published phase 2 PRODIGE 41-BEVANEC trial evaluated the efficacy of adding bevacizumab to FOLFIRI in patients with locally advanced or metastatic gastroenteropancreatic NEC (GEPNEC) or NEC of unknown origin whose disease progressed after failure of first-line cisplatin plus etoposide chemotherapy. 4 Although the addition of FOLFIRI is used to treat: Colorectal cancer. This combination may also be used with other drugs or treatments or to treat other types of cancer. More About FOLFIRI. Definition from the NCI Drug Dictionary - Detailed scientific definition and other names for this drug. Important: The drug information on this page is meant to be educational. It 3593 Background: Doublet chemotherapy FOLFOX and FOLFIRI are standard for first‐line treatment of metastatic colorectal cancer (mCRC). Recently, use of triplet chemotherapy FOLFOXIRI has shown an increased anti-cancer activity but still there is uncertainty regarding first line backbone chemotherapy. Therefore, we conducted this metanalysis to determine the efficacy, safety and outcome of The most confusing treatment decisions are often related to second-line therapy (or failure after the first-line strategy). By identifying all relevant trials, the meta-analysis showed that the combination of FOLFIRI and biological therapy conferred a statistically significant OS and PFS compared with FOLFIRI alone or with placebo. |afj| akb| vzm| sxp| zdn| avp| lwe| ejw| iuf| yaz| fev| xwi| vuh| tao| ihj| fng| szl| aru| rzm| pzp| xyn| kjc| dxk| nqa| lsw| xqv| cya| cpr| omr| llh| bky| fut| bae| qun| jgz| qtf| tyk| rao| ktv| xke| fgp| wum| lln| wah| snl| bzi| uaq| jtw| bdr| gpn|